It. Gumprecht nuclear shadows or smudge cells are other characteristic morphologic features of cll. The diagnosis of prolymphocytic leukemia is made.
33 in the absence of lymphadenopa thy or organomegaly as defined by physical examination or ct scans. Gumprecht nuclear shadows or smudge cells found as cell debris are other characteristic morphologic features found in cll. In order to confirm the diagnosis the b cell markers on circulating lymphocytes should be characterized to show that the cells are indeed monoclonal.
Shadows around the nucleus are an artifact produced by chromatin fragmentation during preparation gumprecht s nuclear shadow. Cll or sll might be suspected in otherwise healthy adults who have an absolute increase in the clonal b lymphocytes but who have less than 5 10 9 l b lymphocytes in the blood. Gumprecht nuclear shadows or smudge cells found as cell debris are other characteristic morphologic features found in cll.
Might be meant here note added at 1 stunde 2018 10 16 22 12 26 gmt these nuclear shadows are white blood cells leukocytes with broken down nuclei gumprecht s nuclear shadows in. Gumprecht s shadows in peripheral blood smear. Klīn gŭm prekt shadow nuclei in degenerating lymphoidocytes and macrolymphocytes in leukemia.
Article in german müller d ferger w missmahl hp. Origin and meaning of gumprecht s nuclear shadows in chronic lymphatic leukemia. 33 in the absence of lymphadenopathy or organomegaly as defined by physical examination or ct scans cytopenias or disease related symptoms the presence of fewer than 5000 b.
Gumprecht nuclear shadows or smudge cells found as cell debris are other characteristic morphologic features found in cll. He studied medicine at the universities of heidelberg berlin göttingen and jena earning his doctorate at the latter institution in 1889 in 1890 he became an assistant at the krankenhaus friedrichshain in berlin followed by work at the pathological institute and at the medical clinic at the. Ferdinand adolph gumprecht march 18 1864 1947 was a german internist born in berlin.
Basket cell 2 gumprecht shadows shadow cells.
Gumprecht nuclear shadows. Immature leukocytes of any type that have undergone partial breakdown during preparation of a stained smear or tissue section because of their greater fragility. Smudge cells are seen in largest numbers in chronic lymphocytic leukemia.
Smudge cells are seen in largest numbers in chronic lymphocytic leukemia. Immature leukocytes of any type that have undergone partial breakdown during preparation of a stained smear or tissue section because of their greater fragility.
