Twelve specific cytologic features i e two dimensional 2 d groups spindled morphology defined cell borders nuclear enlargement nuclear grooves fine chromatin distinct nucleoli granular cytoplasm nuclear crowding intranuclear pseudoinclusions papillary architecture and mitoses of the atypical thyroid cyst cells were. Although formation of incis is linked to nuclear grooves they seldom exist together. Intranuclear cytoplasmic inclusion inci and nuclear grooves in fine needle aspiration fna smears of papillary thyroid carcinoma ptc represent cytoplasmic invaginations into the nucleus.
Small nucleoli if concomitant thyroid carcinoma types are present solid trabecular insular. Nuclear crowding overlap and elongation. If papillae are present they should comprise less than 1 per cent of the tumour volume unequivocal nuclear features of ptc must be present i e nuclear pallor incis longitudinal nuclear grooves.
1b or aus hc fig. The cases showing dominant microfollicular formation or hürthle cell change without nuclear atypia were subcategorized as aus mf fig. Nuclear atypia included nuclear grooves nuclear inclusions or crowding or overlapping of nuclei but not nuclear enlargement.
However they become an important diagnostic feature when associated with an oval enlarged nucleus with fine chromatin. Nuclear grooves alone are nonspecific and can be seen in a variety of neoplastic and non neoplastic cells including macrophages and benign follicular cells. The grooved nuclei were best identified on papanicolaou stained material.
Nuclear grooves were also observed in two of the 113 non ptc cases 1 8 both of which were colloid nodules one with extensive hurthle cell change. Ovarian tumors including brenner tumors adult granulosa cell tumors and transitional cell tumors. It is a characteristic feature of papillary thyroid carcinoma but has also been seen in other types of thyroid neoplasms as well as in non neoplastic thyroid lesions.
It can be present in. A nuclear groove is an invagination of the nuclear envelope in the longitudinal axis. Of papillary carcinomas 67 6 had or 4 cells with nuclear grooves whereas 0 40 of other thyroid diseases exceeded this level.
In mgg stained smears the number of cells with nuclear grooves 40 7 32 83 sd was also significantly higher as compared to other thyroid disorders p 05 to 001.
