Involved in poly a rna transport. Functions as a component of the nuclear pore complex npc pubmed 11564755 pubmed 11684705. Npcs provide access to the nucleus and regulate the transport of proteins and rna across the nuclear envelope.
Schwartz abstract nuclear pore complexes npcs are indispensable for cell function and are at the center of several human diseases. The nuclear pore complex structure and function at a glance greg kabachinski and thomas u. 2 biochemistry center of heidelberg university inf328 heidelberg d 69120 germany.
1 european molecular biology laboratory structural and computational biology unit meyerhofstrasse 1 heidelberg d 69117 germany. Beck m 1 hurt e 2. Understanding its function through structural insight.
The nuclear pore complex. In this cell science at a glance article and the. They are aqueous channels generated from a complex network of evolutionarily conserved proteins known as nucleporins.
Npcs provide access to the nucleus and regulate the transport of proteins and rna across the nuclear envelope. Nuclear pore complexes npcs are indispensable for cell function and are at the center of several human diseases. They are large macromolecular assemblies with a complex composition and.
Nuclear pore complexes npcs fuse the inner and outer nuclear membranes to form channels across the nuclear envelope. A complex of nuclear pore proteins required for pore function. R meier e bradley p horecka j forbes d.
127 908 921 10 1242 jcs 141739 google scholar finlay d.
Nuclear pore complex function. A nuclear pore is a part of a large complex of proteins known as a nuclear pore complex that spans the nuclear envelope which is the double membrane surrounding the eukaryotic cell nucleus there are approximately 1 000 nuclear pore complexes npcs in the nuclear envelope of a vertebrate cell but it varies depending on cell type and the stage in the life cycle. Interaction of nup53 with ndc1 and nup155 is required for nuclear pore complex assembly.
Interaction of nup53 with ndc1 and nup155 is required for nuclear pore complex assembly. A nuclear pore is a part of a large complex of proteins known as a nuclear pore complex that spans the nuclear envelope which is the double membrane surrounding the eukaryotic cell nucleus there are approximately 1 000 nuclear pore complexes npcs in the nuclear envelope of a vertebrate cell but it varies depending on cell type and the stage in the life cycle.
