Most soluble proteins travel via nuclear pore complexes npcs vast tunnel like structures spanning the nuclear envelope the protective membrane that surrounds the nucleus the command centre. The nuclear pore complex npc perhaps the largest protein complex in the cell is responsible for the protected exchange of components between the nucleus and cytoplasm and for preventing the transport of material not destined to cross the nuclear envelope. It acts as a gatekeeper controlling the transport of molecules between the nucleus and the.
In human cells the nucleus is enclosed by a structure called the nuclear pore complex npc. 1 department of microbiology and molecular medicine university of geneva 1 rue michel servet ch 1211 geneva switzerland. Strambio de castillia c 1 niepel m rout mp.
Bridging nuclear transport and gene regulation. The nuclear pore complex. Although small molecules can enter the nucleus without regulation macromolecules such as rna and proteins require association with transport factors known as nuclear.
The entry and exit of large molecules from the cell nucleus is tightly controlled by the nuclear pore complexes npcs. Nuclear transport refers to the mechanisms by which molecules move across the nuclear membrane of a cell. Emerging evidence suggests it also regulates gene expression by influencing the internal architecture.
The nuclear pore complex is the key regulator of transport between the cytoplasm and nucleus. A nuclear pore is a part of a large complex of proteins known as a nuclear pore complex that spans the nuclear envelope which is the double membrane surrounding the eukaryotic cell nucleus there are approximately 1 000 nuclear pore complexes npcs in the nuclear envelope of a vertebrate cell but it varies depending on cell type and the stage in the life cycle.
